Duggal gu mat sëkk
3,4{3}}Dihydro{6}}2H-pyran (DHP, CAS 110-87-2) ab garab la bu am solo buñuy jëfandikoo bu bari ci defar ay jumtukaayi garab yu am doole (API). Ether heterocyclic bi am 6 cër dafay def liggéey bu am solo ci aar grupu hydroxyl yi jaaraleko ci sos ether tetrahydropyranyl (THP). Limu mëna maske alkol ci biir anam yu asid yu woyof, ba noppi delloo leen ñu set ci biir asid aqueux moo tax mu am solo ci synthese drog ci jéego yu bari.
DHP ñu ngi koy defaree ci hydrogenation dihydropyran wala biomass bu bawoo ci furfural, DHP dafa méngoo ak njàngalem chimie bu wert. Ñaari wareefam yi mu am, di reactif aar ak diggante buy reaktif, moo gëna dooleel njariñam ci defar corticosteroid, antibiotik macrolide, ak inhibitëru protease VIH, ci yeneen API yu am solo lool.
Ay leeral ci produit bi
| Tur produit | 3,4-Dihidro-2H-piran |
| CAS NO. | 110-87-2 |
| Sinonim | DHP |
| Formul molekulaar | C5H8O |
| Kodu HS | 2932999099 |
| Formul jëmmal |  |
Màndarga
|
Ay jumtukaay |
Tolluwaay bu jaar yoon |
|
Melokaan |
Fluid bu leer bu amul melo |
|
Setal (%) |
Lu ëpp wala lu tollu ci 98.5 |
|
Tooyaay (%) |
Lu néew wala lu tollu ci 0.25 |
|
THP(%) |
1.3 lu ëpp |
| Densité (g/cm3) | 0.922 |
Jëfandikoo ak liggéey bu am solo ci synthese farmasi
- Aar Hydroxyl ci defar API:
DHP dañu koy jëfandikoo ngir aar alkol yi ci diggante drog yi, lu ci melni ethers THP. Groupe yooyu dañuy dëgër ci anam yu basic ak nucleophilic te mën nañu leen dindi ci anam wu sell jëfandikoo asid dilué.
- Synthese organik ci jéego yu bari:
Yombal yooni synthese fu alkol-am ci diggante yi wara jaar ci liggéey bu gëna mag te du am benn reaction secondaire.
- Li gëna am solo ci jëfandikoo drog:
Eritromisin (antibiotik makrolid):DHP dañu koy jëfandikoo ngir aar hydroxyl ci diir bi ñuy forme ring.
Kortikosteroid:Dafay aar kuréeli hydroxyl yi ci jamonoy jëmmal ring yu jafe ak jéego oxidation.
inhibitëru protease VIH:Ci garabi peptidomimetik yi, DHP dafay jàppale chaine yi ci wet yi ñu baña gaawa jeex wala ñuy siklisasioŋ.
- Chimie verte diggite:
Mën nañu ko jëlee ci furfural -biomass{1}}base chimik-pose DHP muy diggante buy yàgg ngir jëfandikoo ci farmasi.
Kàttanu liggéey
-Sàrtifikaayu Kaaraange Sikl
Produit yiñ digal ñu jëfandikoo
makrolid ak aminoglikosid
Defar drog steroid (lu melni, hidrokortison, deksametason)
Defar peptide ak drog peptidomimetik
Aar hydroxyl buñ tànnee ci scaffold drog yu am glusid-
Process chimie ngir yokk - kàndidaa klinik yi
Emballage
Ñu tëj ko ci: tambour yu 180 kg (ci mbooloo), butéelu 1L/5L (balansu laboratoire wala pilote)
laaj ak tontu
Laaj: Lu tax DHP am solo ci synthese farmasi?
A: Dafay may aar bu tànneef ci grupu hydroxyl yi, may synthese drog ci jéego yu bari ñu mëna dem bu baax te du am benn reaction secondaire.
Laaj: Ndax mën nañu jëfandikoo DHP ci liggéey GMP?
A: Waaw. DHP bu sell bu kawe, mën na nekk ci environmaa yiñ yamale sudee amna ay leeral yuñ gëm ak ay COA.
Laaj: naka lañuy soppi aaru THP ci synthese drog?
A: THP groupes ñu ngi koy dindi ci asid bu woyof (lu melni asid acetik bu ndoxe), delloosi alkol bi amul dara ngir jéego yi ci topp.
Màndarga
|
Ay jumtukaay |
Tolluwaay bu jaar yoon |
|
Melokaan |
Fluid bu leer bu amul melo |
|
Setal (%) |
Lu ëpp wala lu tollu ci 98.5 |
|
Tooyaay (%) |
Lu néew wala lu tollu ci 0.25 |
|
THP(%) |
1.3 lu ëpp |
| Densité (g/cm3) | 0.922 |
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